Someone asked me a couple of days ago why web references in BizTalk projects use .odx files.   If you show all files in Solution Explorer, and expand a web reference, you will see an .odx (Orchestration Designer) file has been created automatically.
The answer is fairly straightforward.   In a C# or VB.NET project, a web reference results in the generation of 'proxy' source C# or VB.NET code designed to compile down to a class used to invoke a web service.   This proxy code is generated over the WSDL provided by the web service.   If the web service was itself written in C# or VB.NET, then the WSDL reflects the web service class and its 'web methods'.   Hence the proxy class ends up providing a client-side class that is very reminiscent of the server-side .NET code.
Something similar is happening in a BizTalk project.   BizTalk projects use the XLANG/s compiler, rather than the C# compiler, so generated code must be in XLANG/s, and XLANG/s is saved into .odx files.   Hence, each web reference results in an additional 'orchestration', although it is not generally thought of as such.   The compiler compiles this to a proxy class which internally uses the same .NET approach as C# or VB.NET web service proxies.   I assume that these proxies are then used directly by the BizTalk SOAP adapter to invoke the web service.
It is worth noting here the close association between WSDL and XLANG/s.  XLANG/s uses constructs which reflect directly the WSDL view of service descriptions.  Just like WSDL, XLANG/s defines a service as a collection of ports bound to port types representing individual operations which may involve either one-way or two-way message exchanges.   Each message is defined in terms of one or more message parts.  WSDL is typically extended with SOAP-specific elements, but remains a generic service description language.   XLANG/s is structured in the same way as generic WSDL, but includes executable code to provide an entire service implementation.   A BizTalk 2004 orchestration is not itself a web service, but rather a service (derived from the BTXService class) invoked by the subscription service within BizTalk.  It is, however, a natural extension of XLANG/s to implement proxy classes which invoke WSDL-described web services internally.