Well, I just installed Vista 64 yesterday and when I loaded up Sins everything played just fine, but there was white artifacting* around the edges of ships, planets and debris. I played a full game for three hours or so and never had a crash or a hiccup except for this.
I'm guessing it's a driver thing. And no, I'm certain it isn't heat related.
Specs:
Athlon X2 5600+ 2.8ghz
Asus M2N32-SLI Deluxe
4gb Mushkin DDR2 800
EVGA 8800GTS 640mb
Driver: ForceWare 169.38 Vista 64-bit
Honestly, I didn't try another driver yet, seeing as how I spent quite a few hours yesterday installing Vista and whatnot.
I'll post up a screenshot later.
*Note: I don't think artifacting is the word I want, but I can't think of a better one right now.