Here's a question: Do you have a Mod selected to automatically load on Startup? I'm having the same issue, but just realized that I have a mod set to load. Although I uninstalled Sins and re-installed on Impulse to no availe, I noticed that on uninstallation it still left a lot of files in my Sins directory. I'm trying to uninstall, delete the entire folder, and reinstall. Hopefully that will do the trick.
EDIT: Deleting the Sins folder did not do the trick, however deleting the mods in my MODS folder did! I can now load the game, woohooo!!!!!
I've ben having the same problem. I uninstalled the game in an attempt to downgrade so I can play a few mods that haven't made the jump yet and it would never load right, even if I deleted the registry. I'm going to try your method and see if it works.
EDIT: Okay, well that didnt work. Wen i try to load the game all it does it gives me a black screen and then dumps me back to my desktop. Anyone have a fix for me?