I have been having desyncs when I play Sins of an Empire.  As a matter of fact, I am pretty fet up now because I have had a desync with every single game that I have played.  I have four other friends that also have Sins, and we have played at least a dozen times with different combinations of the five of us.  Every single time, it is only me that desyncs.  At some point during the game, there will be a conversation of "wow.  you are getting hammered on this planet" or "please help me with this planet."  The response will be "what are you talking about?"  I guess I don't have to explain the desync problem.  But at this point I am disgusted because it has happened every single time.  In the end I always tell them to just go ahead and finish the game without me.  Oh, and after we notice the desync, I will inevitably get a mini-dump somewhere down the road.
So, here is the only thing that I have found that might apply to us.  All four of my friends have a typical intel PC.  Their operating systems are mixed with Windows XP and Vista.  I, on the otherhand, use Windows XP through BootCamp on an Apple iMac.  I guess that's a pretty huge difference in hardware.  As I mentioned, I am the only one to ever desync, so I lean towards thinking that my iMac is the issue.  I have not seen anybody mention anything about Apple computers running Windows, so I am on the verge of giving up.
If there is anyone out there that can possibly offer any advice or any help, I would be ever grateful.  I really like this game and enjoy what I can play with my friends, but I really would like to play a game to completion with them.
Thank you.