A few thoughts on the Advent:
Integrated Defense:
Like their ships, the Advent Starbase needs support id you want them to have much staying power - that means upgraded beam cannons (preferably in clusters of 5), several regeneration bays, and several hangarbays (with fighter and sheild upgrades). If you layout your defenses correctly all of your defensive unitis inculding your starbase are much harder to kill.
Economy:
Maximising your alligance on key worlds is a massive boon to your economy and adding merchant upgrades to starbases in noncolonizable gravity wells extends your trade chain to unbelivable lengths.
Culture:
Besides being absolutely neccissary for your own economy, Advent Culture is your superweapon. If your playing a game long enough to get to super weapons you've had time to build starbases with culture upgrades which don't just spread your culture but repel enemy culture. The key is to get these upgrades early in worlds near but not on your front line. As the game progresses your neigbors will have to invest in lots of cultural centers on their front lines to counter your cuture or lose their front line worlds. This eats up their resources, logistical slots, and dampens their productivity. In large games your culture will quite literally create a buffer zone of worlds taken over by your culture. Combine this with Advent Upgrades and you have the best intelligence in the game. You know where and in what size your enemies are if they are in systems dominated by your culture or 2 jumps away from your systems. Thats a huge advantage when planning strikes or defending your territory.
In general you've got to realize that star bases are part of a long run strategy that out produces and out culture's you're enemies. They don't survive on their own as defensive structures. They require an integrated defense of support structures and fleets - but are very effective when you take a wholisitc approach to defense.