1) the best counter to heavy cruisers are bombers. Other than that, many of the support cruisers are effective at disabling or otherwise thwarting them. The guardian, hoshiko, subjugator, and subverter in particular are your best bets.
2) Again, bombers. They deal the most damage to orbital structures. Other than that, LRF are a good alternative.
3) Vasari are strong early game, and have the ability to negate enemy shield mitigation, making them especially dangerous for destroying enemy capital ships. TEC has the strongest economy and the cheapest ships in general, which gives them the opportunity to field the largest fleet. Advent are late bloomers with exceptionally powerful fleets and by far the most powerful shields, making their capital ships the toughest to destroy (unless you're Vasari...).
4) for Advent, my first three capital ships are almost always the mothership, radiance, and halcyon. I sometimes swap the order of radiance and halcyon, but mothership is always first. This is called the "holy trinity" and they are some of the most powerful capital ships in the game. The other Advent capital ships are good, but not as good.
For Vasari, the evacuator is a must-have first choice. After that, anything is possible; all the Vasari capital ships are well balanced and powerful, and picking the right one for you involves evaluating the situation and making a decision. I personally I like the Vulkoras for bombarding planets, but the Skirantra carrier and Kortul battleship are also two of my favourites.
As for TEC, you usually want to have an Akkan, Marza, and Kol at some point in your fleet. Their abilities are extremely useful. However, Dunovs are excellent for restoring shields and for other support abilities. It's common to see Dunovs working in pairs, so they can restore each other's shields. Sova is a little weird, and often times I ignore it altogether, but in some cases its embargo ability is invaluable.
If you play as the TEC the best cap balance is 4 Kols, 4 Akkens, 4 Marzas, and 4 Sovas. Don't even bother with Dunovs. all they do is waste prescious fleet space.
First of all, it's very rare to get 16 capital ships in a game (unless you're playing games with over a hundred planets). So that's not very useful advice. Secondly, Dunov is an extremely useful capital ship and should not be ignored.