I was Advent Rebel fighting against an Unfair AI's TLT in this situation :-
*I owned the gravity well, had culture, full research (all trees)
*Had a full compliment of tactical modules built up (a bunch of synergied beam arrays, a bunch of hanger defenses, a phase inhibitor and like 3 repair platforms all bunched together near a starbase for sharing the Synergy shield buff all around)
*Maxed starbase "out in front" (closest thing to the enemy ships) with 3 x Preservation and 2 x weapons, the rest of the upgrades I bought were non-combat (trade and culture I think)
*I had a total of like 12 fighter squadrons from the hangar defenses, and allocated them all to fighters because I anticipated an enemy attack with a swarm of their own bombers and didn't want them to take down my Starbase
*About a minute after the enemy fleet hits the gravity well, my own fleet arrives: 2 level 8 Progenitor capships and an level 5 advent rebel titan. I already have my Radiance flagship in the gravity well, but it's hanging back just behind the starbase and the beam arrays so that only the LRMs can attempt to hit it (and it seems they're more interested in hitting the beam arrays anyway).
*I take a look at the enemy fleet and they have a level 4 TLT, 2 Ogrovs, several LRMs, Level 5 and 6 Kols, a level 8 Akkan, 2 level 4 Sovas, a level 6 Dunov, and a total of about 12 assorted frigates/cruisers (percherons, kodiaks and hoshikos).
*The AI rushes my starbase head-on with the softer ships, and the maxed weapons obliterate all but the cap ships and titan in a very short time. This is about when my titan and backup fleet (the 2 Progenitors) arrives. Their titan is still at like 95% shields because it's sitting out of range of the starbase, hammering away at a hangar defense I have sitting out vulnerable on the side of my primary defensive line.
*I go after the TLT with my titan (which is 1 level higher than theirs) and my 2 Progenitors. Later I cautiously throw in the flagship for extra DPS.
*A lot of fighting happens. The end result: I lost a bunch of my weaker modules (beam arrays and mineral extractors, mainly) and my capships had about 50% hull each, but their shields were doing well because I was able to retreat them mid-battle and use the shield restoration ability. The enemy titan fought to the bitter end but was destroyed. It seemed very interested in attacking my flagship and my modules, so my own titan was hardly damaged. I ended up destroying all of the capships, too, because they couldn't retreat; my phase inhibitor was cleverly placed, surrounded by a ring of beam arrays, repair platforms, and the starbase on one side -- so the enemy would've had to target it with their entire fleet from the very beginning in order to destroy it, but since it's the AI, it didn't do that.
*Considering the odds, and considering how heavily I inflicted losses on the enemy while only losing a few modules and taking a lot of hull off of my capships, I think I did pretty well... I was feeling the annoyance of the TLT ability for sure, but I used the gravity well advantage plus things like repair platforms and the starbase's superior firepower to eventually wear down and destroy the titan. Basically it tried very hard to punch through my defenses, but I had so much pushback built up that it wasn't able to break through. And it couldn't repel the damage being dealt by my starbase indefinitely, because even against a titan that thing can DEAL. I used my flagship to lure the titan into range of all three of my starbases's weapons, and it didn't last very long after that (especially while being targeted full blast by my own titan).
I also used the mobility of my reinforcing fleet to my advantage: I killed their Ogrovs right at the very beginning of the battle, because I knew my titan and capships could withstand a little heat in order to destroy the Ogrovs before retreating back within range of my modules, which then provided a lot of much-needed soaking up damage from the capships and titan.