While playing sins, I bring up the menu to pause the game,
I'll gain control over my second machine using multiplicity, and if I don't do
what I want to do fast, when I come back to the game I won’t be able to click
on anything. The mouse-over effects still work, but when I try to click it won’t
go through. Alt-tabbing and returning has a slight chance of fixing it, but the
problem usually returns within a few minutes of play. The only way to
"fix" it is to restart the game, which is annoying when all you want
to do is respond to someone sending you an IM. My main machine is Vista 64 bit, with SP1, and my second machine is XP 32
bit, with SP2. Running Multiplicity version 1.21.
If you need anymore information, I'll try to provide it.