Okay, I saw this problem when I tried to run Silveressa's Empowerment v1.1 using v 1.04 of Sins. When I enable the mod and start a new game, I immediately hear a message stating that I've lost a planet (my homeworld, presumably) and get the game over screen. I thought maybe it was a bug with the mod so I disabled it, but I'm finding in tweaking with my own custom mod that I've gotten myself to a state where this happens with my files.
Anyone bumped into this before?