This is the one that appears by going through the Start menu. and says it's "Sins of a Solar Empire". It's not, though, it's linked to SINS_Launcher, which appears to do nothing but create a taskbar button and that's it (game doesn't launch).
The start menu shortcut is supposed to point to the launcher; if the launcher is not working, chances are you've got an antivirus that's blocking it.
To run the game I too had to eject then reinsert the DVD.
The disc isn't required to play.