Something similar happend to me. This little box comes up as well:
Program: ...ardock\Sins of a Solar Empire\Sins of a Solar Empire.exe
This application has requested the Runtime to terminate it in an unusual way. Please contact the applications support team for more information.
Sins worked well in the morning but not in the afternoon, Sunday the 16th
I did however install some updates of Gal Civ 2 in the morning if that could have an impact?
(I'v reinstalled sins, updated my drivers and deleted the settings as well) Nothing works