CB has a charge time of 2 seconds and a duration of 8 seconds, so if you can count time accurately, order the Radiance to fire on a target which can withstand the 2000 damage CB will do over those 8 seconds (preferably a capital ship, though with the huge hull and shield buffs to light carriers, those could work), count 2 seconds and cast Malice immediately.
Really, capital abilities work most optimally when microed properly. Malice could also work if you have lots of ships pouring on damage really quickly, but since ships tend to focus fire, its far less effective than used with an AoE attack.