1.) As Malice is omni directional, always cast it after you see your radiance lining up. requires only minimal learning.
2.) Aim for carriers/caps preferably, they take the whole cb volley
3.) For added effect, try to at least hit 2 targets with the beam that are under the effect of malice. effectivly doubles malice damage.
4.) Have your radiance OUTSIDE of your main fleet. do not include it. let it roam freely. it will increase its mobility a lot and lets you use cb from a flanking position (meaning you'l probably hit more stuff)
5.) Combine with volatile nanites for added effect.
6.) Combine with Missile barrage for added effect.
7.) Combine with Volatile nanites and missile barrage to destroy the universe.