Well it, depends on the map. On some, going tutle is a viable option, and just waiting for them to outproduce themselves trying to crack open your homeworld, eventually obliterating their economy, while leaving yours thriving with plenty of surplus.
Advantages: One defensive position. Strong defenses, centralized area, easy micromanaging, predictable jump in-out points.
Disadvantages: If you lose, you're done. AI can grab up the other planets. Nonstop fighting. It can wear you down.
Best on small maps. This is personally may favorite tactic, and I've used it to great effect before, especially on Point Blank.
Medium+, go with previous suggestions. Chokepoints are great, especially considering the AI doesn't know how to make heads or tails of a starbase, coupled with hit and run (I prefer a Kol-Dunov pair to do this, no other ships) behind their lines to keep pressure on them and to draw forces away from your front.

Cadalancea