It's a very small, yet extremely aggravating issue.
When playing Rebellion in fullscreen mode, hte mouse can still pass between screens. It prevents me from panning right on the map (in my case, depends on what screen others play on), and if I accidentally click when not on the game screen, the game will minimize.
The issue is fixed by disabling the second monitor, but this is a unneeded burden. I have to move ALL of my desktop icons that are on that screen and my taskbar (since my taskbar is on the screen I do NOT play games on) to the screen I will play Sins on, then disable the monitor. When I'm done, I have to re-enable the monitor then move all my shortcuts back into the right positions.
It makes the game a lot less playable, because it forces me to spend five minutes reorganizing things. Please make full-screen mode fullscreen again.