You can use Task Manager (as mentioned by Fairyy), which you can invoke directly by hitting "Ctrl+Shift+Esc" > click the Processes tab > select any "widget.exe" listing > click "End Task" button for each.
After killing the widgets, unload DesktopX if it is running and clear the widget cache by deleting the Widget Cache folder found in "C:\Documents and Settings\USERNAME\Local Settings\Application Data\Stardock\DesktopX" folder.
For instructions on clearing the cache, you can see my mini tutorial here http://corkyo.wincustomize.com/Articles.aspx?SID=5463&AID=82461
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