Dragon Age, Hearts of Iron III, Majesty II, Elemental. I'm up in the air on Bioshock II--I loved the first game (even though I am not usually a shooter fan), but am ambivalent at best about playing as a Big Daddy.
The Star Wars MMO looks interesting, but I've tried virtually every major MMO and none have come close to living up to original EverQuest, which I played compulsively for five years. Basically, they have all followed WoW in dumbing down and watering down the old EQ experience--little to no death penalty or corpse recovery, easy soloing to max level, extreme handholding via the quest structure. I know I am in a clear minority these days, but EQ's death penalty, CR, and forced grouping not only taught people to play their class and created a social dynamic unrivaled in any other MMO, but the very real potential penalties was a major factor in making EQ the compelling experience that it was. My hand literally shook the first time I stood at the portal waiting to zone into the Plane of Fear.
Unlike many posters, I am not particularly looking forward to Mass Effect II. I never got too far in Mass Effect I (I finished the initial Citadel quests and just scratched the surface of the planeary missions, though I keep meaning to go back) . Although I found the both the story and setting quite compelling, ansd the voice acting top notch, these positive factors were overshadowed by the gameplay--combat was too console oriented and twitch dependent for my tastes and, as per usual with Bioware games, the "zones" were rather restrictive and smaller than they appear (I much prefer the open world environments in Bethesda games,). As an old, old (55) gamer brought up on stat based RPGs and lacking the manual dexterity of a teen, my interest goes down as the twitch factor goes up.