Upon autosaving for the second time, there is a slight chance that the game will lock up, forcing me to Ctr+Alt+Del to get out. Usually, the problem resolves itself within a day or so, but there have been times that it has persisted for days in a row... And here is someone else with the same problem. (Hope he doesn't mind being quoted)
"I played a game today from start to finish no problem, I started another one this evening and I got a minidump on autosave-2."
~Houseaddict~
The problem is not constant, but rather appears to come and go...