As a matter of fact, i had this several times. And i did not even mess with the game files, playing for unlocked races, or anything. I had run-time error while playing for TEC before, and yesterday, as the 0.76 version downloaded, i tried my Advent Loyalist save from last weekend, and after perhaps 20-30 minutes of play, the game crashed to desktop. It happen very fast this time, but i reckon i saw there the RunTime Error table to flash there for a moment (before it would stay there and i could click the OK button)... there is sadly no minidump, when this happens, for me to send to the devs. I was under impression before, it was kinda connected to Antivir updating, as it there was strange coincidence, but this was not true yesterday anymore, so do not really see any reason for the crash, seems kinda random.
That said, i have both my CPU and GPU overclocked (although only mildly and do not seem to suffer any issues with other apps or games), but you never know, it may be somehow related. I could overclock my gtx590 from 607 to 775 Mhz and it would be stable for an hour while rendering picture with Octane Render using both GPU cores to full, but it would crash on 720 MHz using one core only while playing StarCraft 2 within several minutes.