I have the same problem with my 64-bit Vista Ultimate SP1 with it (totally) locking up about a minute into the tutorial. Have to hard reset the machine to bring it back up. Running Radeon 4870 (Catalyst 8.9), 4GB RAM, Q9450. Have had no problems in the past with Vista running a wide range of current games and none with the couple of games I've installed over the weekend. I will most likely return Sins to store unless I find a full fix quickly.
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