I personally have one of those gaming comps, even that i love to get as much ram as possible, Star trek mod

redeuce the number of gui things you see, and like what worstfear said, details can be turn all the way to lowest, turn video down to the lowest resolution, and the anti-alaising to none, team colors will help and in the user settings here is what i have,

UseColoredSkybox FALSE

UseDeepSpaceSkybox FALSE

EnableAutoStrafe FALSE

ShowUserInputOnInfoCards FALSE

ShowCargoShipMainViewIcons FALSE

ShowMeshPlayerOwnerIconAlways FALSE

ShowMeshTeamColor FALSE

ShowInfoCards FALSE

ShowGravWell FALSE

ShowIntroMovies FALSE

ShowOpeningCinematic FALSE

NVPerfHUDEnabled FALSE

MeshMock FALSE

ShowAsteroids FALSE

ShowElevators FALSE

ShowDustClouds FALSE

ShowPlanetRings FALSE