I'm a experience mod user/author from Bethesda Games, like Elder Scrolls/Fallout. I've been trying a different mods for SotSE, didn't know there was a 2 gig limit on Sin's, which is very similar to games before Skyrim. So I had a few out of memory crashes in large games.
So I've used CFF explorer to set the LAA flag on SotSE exe, and I've haven't had a problem since. LAA flag will only let it use 3 gigs regardless if your computer uses a 32bit OS, but that's better than 2. More if you have a 64bit OS.
http://www.ntcore.com/exsuite.php
And before you say doing this causes more problems, I use Vista 64 Ultimate, its a lot more stable, windows 7/8 causes more problems for gaming rigs then it solves. Until MS totally shuts support for Vista in 2017, not switching.