I'm running Sins on a Vista Home computer connected to a Vizio HDTV. Some programs don't react well to that arrangement. Sins was okay up until I switched it to windowed mode from full screen. Now, no matter what I do, when the game is the active application the mouse cursor shoots to the top left corner of the screen. There are other games that have done the same thing and I still haven't found a fix for them. But at least the mouse in Sins was working properly when the game was full screen.
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