http://cosmicsupremacy.com
This is a one man project which I followed for few years now. If you tried the BETA for this before be warned, lot has changed. Game is now a lot more complex, but it still maintains the moo2 feel. There are few more jobs for your citizens, like Banker and Miner. There are many new buildings and a lot of tech.
You can now customize your civilization using points and using DOCTRINES, which are researched in the tech tree.
The client is very robust 2 window model. One window for your galaxy view, the other for everything else. It is good design. The client is very small download. And the game is launched by goign tot he website and downloading a pass.
This game is a Free MMO but there is a SP galaxy used for testing.